Pouria Mistani, PhD · Physical AI

GPU-accelerated physics simulation, scientific ML, and the platforms that ship them.

Research engineer at the convergence of large-scale physics simulation and AI — a scientific-startup builder who invents algorithms and ships industrial platforms from scratch. From cosmological simulations on national supercomputers, to tissue-scale bioelectric simulations, to GPU-accelerated ML-potential driven molecular dynamics, to exascale electromagnetics for chip tape-out. 9+ publications. 4 patents.

Trajectory · 2013 → now

One pursuit — high-fidelity, large-scale simulation of physical systems. Five threads, weaving into a single constellation.

  • Astrophysics & cosmology
  • Numerical methods & HPC
  • AI for simulation
  • Biophysics & life sciences
  • Chip design & semiconductors
Career trajectory of Pouria Mistani — milestones plotted across five thematic threads from 2013 to present. 20132016201720182020202120222023202420252026 Illustris · dwarf galaxies MNRAS · dwarf galaxies & globular clusters PhD · UCSB · level-set PDE methods Epitaxy · island dynamics on quadtree grids Physics-aware NN — first investigation AVICENNA · tissue-scale simulation BiPDE · physics-aware neural networks JAX-DIPS · differentiable PDE solver Postdoc · biotherapeutics HPC NVIDIA · Clara, Modulus, Warp Prescient Design · protein design Multi-objective DPO for protein design Synopsys · founding engineer, GenAI Solutions Stealth · agentic physics intelligence Stencil · community journal + agent plugin

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Pattern

Four founding-engineer roles in five years.

I show up early, build the first thing that ships, and grow what works — in both startups and big tech.

  1. 01 2021

    NVIDIA Clara Discovery Simulation

    Founding member. AI-driven drug-discovery simulation team — DiffDock in BioNeMo, GPU-optimized ML-driven MD.

  2. 02 2024

    Synopsys GenAI Solutions

    Founding engineer. GenAI SDK and multi-agent EDA framework adopted across business units; patent lead author.

  3. 03 2024

    Aikium Computational platform

    Founding scientist. Invented multi-objective DPO; 3 provisional patents in four months. The algorithm later became the foundation of Aikium's production drug-design platform.

  4. 04 2025

    Stealth Startup Physical design & verification · Sequoia-backed chip design

    Founding engineer. Designed and built an agentic physics-intelligence platform that reasons about physical design.

Current focus

Revolutionize chip design at the intersection of AI and large-scale simulation — agents that operate, build, and run experiments in silico.

Chip design is the right problem at the right time. The physical models are well-posed and exhaustive — Maxwell, transport, level-set evolution of free boundaries in epitaxy, etching, lithography. The scale is commercially significant. The compute is real. It is the right mix for the methods I've spent a career building, and the natural place to reproduce, in commercial technology, what Illustris achieved for cosmology.

Selected work

Six projects worth knowing about.

Talks

Selected talks.

Get in touch

Working on chip design, AI for physics, or large-scale simulation? Let's talk.